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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Creatine
Research Papers that Mention the Interaction
“The nutritional supplement creatine monohydrate has been reported to reduce symptoms of depression in female adolescents and adults taking antidepressants , as well as to increase brain phosphocreatine in healthy volunteers.”
Creatine as a Novel Treatment for Depression in Females Using Methamphetamine: A Pilot Study“These results indicate that the antidepressant-like effect of creatine … mediated by an activation of α1-adrenoceptor and that creatine produces synergistic effects … TST with antidepressants that modulate noradrenaline transporter, suggesting that an improvement in the response to … antidepressant therapy may occur when creatine is combined with these antidepressants.”
The activation of α1-adrenoceptors is implicated in the antidepressant-like effect of creatine in the tail suspension test“With combined creatine and exercise, 5-HT positive cells increased significantly and had a synergic effect on both DR and MnR. [Conclusion] The present study found that even a single treatment of creatine or exercise has partial effects as an antidepressant in mice with chronic mild stress-induced depression.”
Effects of creatine monohydrate supplementation and exercise on depression-like behaviors and raphe 5-HT neurons in mice
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