Possible Interaction: Antidepressive Agents and Cocaine

“Alcohol, cocaine or benzodiazepines when concomitantly consumed with antidepressant treatment may increase the risk for acting out.”

“However, in preclinical and clinical trials, a variety of compounds were tested for suitability as inhibitors of craving for and relapse into the use of cocaine , among these antidepressants , antiepileptics, dopamine agonists, disulfiram, and naltrexone.”

“Common substances that can interfere with BP control include nonsteroidal anti-inflammatory drugs (NSAIDs), oral contraceptives, glucocorticoids, antidepressants , decongestants, alcohol, or other stimulants like cocaine and methamphetamines.”

“This phenomenon may explain the additive antidepressant action of DHEAS and cocaine and why co-administration of DHEAS and cocaine increases drug use.”

“Treatment of FSL rats with the antidepressant desipramine raised cocaine‐ and GBR‐12909‐induced dopamine release to the level of controls.”

“ConclusionsThe present data show that cocaine is more disruptive to learning in rats than pregnanolone or lorazepam, and that the disruptive effects of cocaine can be enhanced by CNS depressants.”

“The effects of the stimulants such as amphetamine and cocaine are antagonised during the initial depressant phase and unaffected or even potentiated during the subsequent stimulant phase.”

“However, when compared to respective age-matched controls, antidepressant pre-exposure decreased the magnitude of conditioning at the 5 and 7.5 mg/kg cocaine doses.”

“CONCLUSION: These results suggest that drug- and region-specific alterations of MT(1)/MT(2) mRNA produced by protracted antidepressants and cocaine treatment may alter MT1/MT2 expression and contribute to long-term neuroplastic effects of these drugs.”