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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Choline
Research Papers that Mention the Interaction
“In conclusion, significant increase in choline to creatine ratio from the first to the second spectroscopic scan during the antidepressant treatment, compared to almost identical values of NAA to creatine ratio, suggests increased turnover of cell membranes as a mechanism of the early response to the antidepressant drug therapy.”
Changes in brain metabolites measured with magnetic resonance spectroscopy in antidepressant responders with comorbid major depression and posttraumatic stress disorder.“With antidepressants RBC‐choline and choline ratios were slightly reduced (P < 0.05), whereas neuroleptics showed no effect on choline levels.”
“We previously found that choline supplementation increased adult hippocampal neurogenesis, a function compromised by stress, lowered in depression, and boosted by antidepressants ; and increased levels of growth factors linked to depression, like brain-derived neurotrophic factor.”
Supplemental dietary choline during development exerts antidepressant-like effects in adult female rats“All tricyclic antidepressants tested inhibited in a dose-dependent manner the high-affinity choline uptake in the three regions, amitriptyline being the most potent.”
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