Possible Interaction: Antidepressive Agents and Cannabinoids

“Evidence is increasingly accumulating that cannabinoids might play a role in fear extinction and antidepressive effects.”

“When compared with those not taking nabilone, patients using this cannabinoid had a lower rate of starting nonsteroidal anti-inflammatory agents, tricyclic antidepressants , gabapentin, dexamethasone, metoclopramide, and ondansetron and a greater tendency to discontinue these drugs.”

“The findings suggest that cannabinoids may prevent both depressive‐ and PTSD‐like symptoms following exposure to severe stress and that alterations in BDNF levels in the brains' fear circuit are involved in these effects.”