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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Antidepressive Agents and Cannabidiol

Research Papers that Mention the Interaction

Recent evidence suggests that CBD promotes both a rapid and a sustained antidepressant effect in animal models.
Journal of Chemical Neuroanatomy  •  2019  |  View Paper
As expected, CBD has been reported to interact with anti-epileptic drugs, antidepressants , opioid analgesics, and THC, but surprisingly, it interacts with several other common medications, e.g. acetaminophen, and substances including alcohol.
Journal of General Internal Medicine  •  2021  |  View Paper
Altogether, our results indicate that CBD regulates DNA methylation in brain regions relevant for depression neurobiology, suggesting that this mechanism could be related to CBD-induced antidepressant effects.
Behavioural Brain Research  •  2020  |  View Paper
Conclusions Further pharmacokinetic examination of the interaction between CBD and citalopram/escitalopram is clearly warranted, and clinicians should be vigilant around the possibility of treatment-emergent adverse effects when CBD is introduced to patients taking these antidepressants.
Journal of clinical psychopharmacology  •  2021  |  View Paper