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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Caffeine
Research Papers that Mention the Interaction
“Emerging evidence indicates that caffeine enhances the antidepressant-like activity of common antidepressant drugs in rodents.”
“However, whether joint administration of low dose of caffeine enhances the antidepressant actions in depressed patients remains unclear.”
Low dose of caffeine enhances the efficacy of antidepressants in major depressive disorder and the underlying neural substrates.“ Caffeine use was associated with higher antidepressant dosages.”
“Thus, caffeine can interact with a wide range of psychiatric medications, including antidepressant agents , antipsychotic agents, antimanic agents, antianxiety agents, and sedative agents.”
“ConclusionsWithdrawal of caffeine after its chronic intake can modify the activity of antidepressants.”
“&NA; Recent preclinical and clinical data suggest that low dose of caffeine enhances the effects of common antidepressants.”
“The results show that withdrawal of caffeine after its chronic intake may change activity of antidepressants with concomitant alterations within monoamine, adenosine and glutamate systems.”
“SIGNIFICANCE Ca feine po tentiates the activity of ant idepressant drugs fr om different chemical groups.”
“Our previous studies showed that some of the tested antidepressants (tricyclics, SSRIs, mirtazapine, nefazodone) directly inhibited the metabolism of caffeine when added in vitro to liver microsomes.”
“We conclude that the tested antidepressant drugs may affect the metabolism of caffeine not only in a direct way (binding to the enzyme), but also indirectly via inducing CYP1A2 (sertraline and mirtazapine) and CYP2C isoforms (fluoxetine, sertraline, mirtazapine) after prolonged administration.”
“Social isolation modulates sensitivity to psychoactive substances: it potentiated the depressive and analgesic effects of morphine, but attenuated the activating and anxiogenic effects of caffeine.”
Effect of Social Isolation on Behavioral Parameters and Sensitivity of Rats to Morphine and Caffeine“In summary, we have observed intra- and inter-drug differences in the inhibitory effects of the antidepressants on the four oxidation pathways of caffeine in rat liver microsomes.”
“6 Antagonism of the inhibitory effects of the antidepressants on neuronal firings by caffeine , indicates that these compounds can enhance the extracellular levels of endogenously released adenosine sufficiently to depress cell firing.”
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