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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arginine
Research Papers that Mention the Interaction
“In Tricyclic antidepressant toxicity, R in aVR more than 3 mm is an adverse prognostic sign.”
Lead aVR--the neglected lead.“Objective We investigated whether the … oxide (NO) precursor, l-arginine , can prevent the antidepressant-… action of the fast-acting antidepressant , ketamine, in a genetic rat model of depression, and/or induce changes in the glutamate (Glu)/N-methyl-d-aspartate receptor (NMDAR)/NO/cyclic guanosine monophosphate (cGMP) signalling pathway.”
Nitric oxide involvement in the antidepressant-like effect of ketamine in the Flinders sensitive line rat model of depression“Moreover, enhancement of NO synthesis by l-arginine reversed the effect of SSRI antidepressants , further demonstrating the role of NO in regulating the marble-burying behavior.”
“Thus, … antidepressants or antipsychotics could … metabolic pathway of arginine to yield urea or nitric oxide/nitrogen gas, increasing (if AP) or decreasing (if AD) urea or nitric oxide/nitrogen … and, secondarily, excitatory glutamic acid and/or inhibitory gamma aminobutyric acid levels via different pathways in the central nervous system.”
Influence of drug treatment with antidepressants and antipsychotics on plasma urea levels
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