Possible Interaction: Antidepressive Agents and Antioxidants

“This interesting analysis suggests that augmentation of antioxidant defenses may be one of the mechanisms underlying the neuroprotective effects of antidepressants in major depressive disorder therapies.”

“These studies suggest that augmentation of antioxidant defences may be one of the mechanisms underlying the neuroprotective effects of antidepressants in the treatment of MDD.”

“Targeting these pathways has the potential to yield antidepressant effects, e.g. using cytokine antagonists, minocycline, Cox-2 inhibitors, statins, acetylsalicylic acid, ketamine, ω3 poly-unsaturated fatty acids, antioxidants , and neurotrophic factors.”

“These findings support the hypothesis that the antidepressant activity may be at least partially explained by the improvement of antioxidant functions (1).”

“Lowered antioxidant capacity , causing increased oxidative stress, may be involved in affective disorders and might be altered by antidepressants.”

“Meanwhile, the antioxidant levels are increased and the oxidative damage product levels are decreased after antidepressant medication.”

“ Antidepressant treatment for 12 weeks results in increased antioxidant capacity and a decrease in circulating free radicals.”

“Our results revealed that antidepressant treatment induced the antioxidant defense , by decreasing erythrocyte susceptibility to lipid peroxidation and increasing glucose-6-phosphate dehydrogenase activity.”

“In addition, after long-term treatment, significant increases in the mRNA levels were seen in the cases of Cu, Zn superoxide dismutase, gamma-…(-7) M. Based on the large number of significant effects of all types of antidepressants tested on various antioxidant enzymes, we suggest that antioxidant … antidepressive treatment.”

“A varying character of treatment response under conditions of routine treatment by antidepressants combined with antioxidants is discussed in different clinical varieties of treatment-resistant endogenous depressions.”