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Last Updated: 3 years ago
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“Measurement of hormone concentrations revealed an enhanced release of adrenocorticotropic hormone and growth hormone in response to stress of hypoglycaemia in subjects treated with both antidepressants used.”
Enhancement of stress-induced pituitary hormone release and cardiovascular activation by antidepressant treatment in healthy men“Some antidepressant drugs , such as tianeptine, which were found to modulate ACTH release, appear to interfere with brain glutamatergic system.”
“ Corticotropin (ACTH), but not cortisol, responses were blunted in depressives.”
“ Depressive‐mice showed concomitant HPA axis dysregulation as observed from the significant increase in serum CORT and ACTH.”
Antidepressant activity of vorinostat is associated with amelioration of oxidative stress and inflammation in a corticosterone-induced chronic stress model in mice“Chronic daily administration of adrenocorticotropic hormone (ACTH) or corticosterone can alter behavioural responses to antidepressants , effectively blocking antidepressant efficacy.”
“Taken together these results indicate that pre-treatment with ACTH (100μg/day; 14 days) blocks the antidepressant effects of imipramine (10mg/kg), significantly alters key PFC monoamine responses to stress and downregulates glucocorticoid responses.”
“Previous studies have shown that the antidepressive‐like effect of tricyclic antidepressants is blocked by repeated treatments with adrenocorticotropic hormone (ACTH).”
“We have already reported that in rats, repeated adrenocorticotropic hormone (ACTH) treatment blocks the effect of tricyclic antidepressants in decreasing immobility time in a forced swim test, a widely used animal experiment for predicting antidepressant activity.”
“We have already shown that the antidepressant-like effects of tricyclic antidepressants in the rat forced swim test (FST) are blocked by chronic treatment with adrenocorticotropic hormone (ACTH).”
“We have already shown that the antidepressant-like effects of tricyclic antidepressants in the rat forced swim test are blocked by repeated treatment with adrenocorticotropic hormone (ACTH).”
“Thus, ACTH seems to play a key role in decreasing the duration of immobility time of antidepressants in this test.”
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