Possible Interaction: Antidepressive Agents, Tricyclic and Yohimbine

“The side effects lasted for about 4 h. The study has extended the conclusions obtained in animals [2] and healthy volunteers [3] by demonstrating that acute administration of oral yohimbine also increased salivary secretion in patients treated with tricycle antidepressants.”

“ Yohimbine (10 mg) increased both salivary outflow and plasma noradrenaline levels for 4 h. Pharmacokinetic parameters (t1/2, tmax, Cmax and AUCexp) and plasma concentrations of noradrenaline were higher in patients treated with tricyclic antidepressants than in controls.”

“In depressed patients treated with tricyclic antidepressants (and exhibiting a reduced salivary flow), yohimbine also acutely increased salivary volume.”

“ Yohimbine should be administered with caution to patients with high BP, especially in individuals with evidence for increased basal sympathetic outflow or those undergoing concurrent treatment with tricyclic antidepressants or other drugs that interfere with neuronal uptake or metabolism of NE.”

“It was investigated whether yohimbine , a primarily α2-receptor blocking agent, may have an antidepressant effect when given in addition to tricyclic antidepressants.”