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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Tryptophan
Research Papers that Mention the Interaction
“The ratio … plasma of Trp to the sum of the other large neutral amino … (LNAA) was significantly inversely correlated with improvement on TCA , and patients with ratio Trp/LNAA below the mean improved significantly more than patients with a higher ratio but with comparable serum steady-state drug levels.”
5-HT uptake inhibitors and tricyclic antidepressants: relation between trytophan availability and clinical response in depressed patients“Other studies have shown that the prolactin response to tryptophan is also enhanced after long-term tricyclic antidepressant treatment in depressed patients and after short- and long-term lithium treatment in healthy subjects.”
“Other combinations with tricyclics have been reported less frequently: ECT, neuroleptics, reserpine, carbamazepine, 5 HTP, tryptophan , amphetamines, oestrogens, sleep deprivations.(ABSTRACT TRUNCATED AT 250 WORDS)”
“The combination of monoamine oxidase inhibitors and tryptophan (Coppen et al., 1963; 1967), and tricyclic antidepressants e.g., chlorimipramine and tryptophan (Walinder et al., 1975), may increase 5-HT concentrations at receptor sites and therefore be more effective as an antidepressant than tryptophan alone.”
“Changes of tryptophan concentration have also been described to modify the activity of benzodiazepines and tricyclic antidepressants.”
Effect of different psychoactive drugs on serum and brain tryptophan levels.
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