Possible Interaction: Antidepressive Agents, Tricyclic and Epinephrine

“Patients at higher risk for serious adverse effects from epinephrine are those with comorbidities such as underlying heart disease and those taking monoamine oxidase inhibitors, tricyclic antidepressants, antiarrhythmics, and cocaine [8].”

“Adding epinephrine , however, introduces the possibility of a drug interaction with tricyclic antidepressants and nonselective /gb-blockers.”

“ TCA drugs caused an increase in escape time and a decrease in spontaneous rate of spontaneously automatic Purkinje fibers equilibrated with epinephrine (10−7 M) in 5 × 10−5 M EDTA.”