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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Anticonvulsants
supplement:
Glycine
Research Papers that Mention the Interaction
“ Glycine thus potentiates anticonvulsant effects , but only of some drugs and only in some of the seizure models.”
Glycine potentiates the action of some anticonvulsant drugs in some seizure models“ Glycine blocked the anticonvulsant effects of felbamate on electroshock- and NMDA-induced seizures in mice.”
“This study evaluated a possible mechanism by which glycine potentiates the activity of anticonvulsant drugs against maximal electroshock seizures in rats.”
“Although the mechanism may not be mediated by a glycine-GABA interaction, the evidence does implicate a possible interaction between glycine and anticonvulsant drugs at NMDA receptors.”
“ Glycine also potentiated the anticonvulsant actions of MK-801 and diazepam but did not improve the selectivity of the drugs, as effective doses were still associated with neurotoxicity.”
“The lack of interaction between MK-801 and glycine was unexpected considering that glycine potentiates MK-801 receptor binding as well as the activity of other anticonvulsants.”
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