Possible Interaction: Anticonvulsants and Folate

“Increased rates of folate catabolism and simultaneous folate deficiency occur in several physiological states, including pregnancy, cancer, and when anticonvulsant drugs are used.”

“There is also evidence suggesting an interaction between anticonvulsant drugs and folate balance.”

“These findings indicate that epileptic patients receiving anticonvulsants may have a higher folate requirement to maintain a normal tHcy level, especially homozygotes for MTHFR 677 C --> T mutation.”

“ Anticonvulsants other than sodium valproate tended to lower serum folate level.”

“In epileptics on anticonvulsants, folate deficiency often occurs because anticonvulsants inhibit folate absorption.”

“Our findings show that all anticonvulsant drugs interfere with folate metabolism.(ABSTRACT TRUNCATED AT 250 WORDS)”

“ Anticonvulsant (folate antagonists) therapy had a significant influence on the folate status demonstrated with radioimmunological technique.”

“While the term "drug-nutrient interactions" tends to conjure up a concept of an adverse combination, such as anticonvulsants impairing folate metabolism or alcohol blocking active thiamine absorption, there are situations in which a drug and nutrient can act in a complementary manner, to correct a metabolic defect.”

“In Reynolds's study3 folate seemed to render the anticonvulsants less effective, though frequency of fits was not affected by folate supplements in the present work.”

“between concentrations of serum folate and those of anticonvulsant, impairment of folate absorption by anticonvulsant is usually presumned to be the cause.”

“In Reynolds's study3 folate seemed to render the anticonvulsants less effective, though frequency of fits was not affected by folate supplements in the present work.”

“between concentrations of serum folate and those of anticonvulsant, impairment of folate absorption by anticonvulsant is usually presumned to be the cause.”