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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Anticonvulsants
supplement:
Cannabidiol
Research Papers that Mention the Interaction
“These findings suggest that cannabidiol could be exerting its anticonvulsant effects , at least in part, through its actions on voltage-gated sodium channels, and resurgent current may be a promising therapeutic target for the treatment of epilepsy syndromes.”
Aberrant epilepsy-associated mutant Nav1.6 sodium channel activity can be targeted with cannabidiol.“Interestingly, cannabidiol attenuated the anticonvulsant activity of levetiracetam.”
Acute effect of cannabidiol on the activity of various novel antiepileptic drugs in the maximal electroshock- and 6 Hz-induced seizures in mice: Pharmacodynamic and pharmacokinetic studies“Furthermore, it appears that CBD enhances the anticonvulsant effects of the former and reduces the effects of the latter types of antiepileptic drugs.”
“Cannabidiol has well-described inhibitory action on cytochrome P450 (CYP450) drug-metabolizing enzymes and significant drug-drug interactions (DDIs) between CBD and various anticonvulsant medications (eg, clobazam) have been described in the treatment of epilepsy.”
Citalopram and Cannabidiol
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