Possible Interaction: Anticonvulsants and Caffeine

“ Caffeine reduces the efficacy of several anti-seizure medications , especially topiramate.”

“ Acute caffeine , in doses far below its convulsive potential (almost 10-20 fold lower than the ED50 of the … of 2.03 mmol/kg for the induction of seizures), produced a significant reduction in the anticonvulsant effects of carbamazepine, phenobarbital, phenytoin, and valproate … maximal electroshock-induced seizures in mice.”

“The overdose of caffeine produced a clinical picture that suggested neonatal seizures and prompted therapy with anticonvulsants.”

“Moreover, caffeine prevented from dantrolene anticonvulsant effects.”

“Pre-treatment (intraperirhinal cortex) of animals with the nonselective adenosine antagonist, caffeine (50 microM; 1 microl), blocked the anticonvulsant activity of 2-CLA.”

“Intraperitoneal but not intrahippocampal pretreatment of animals with caffeine (50 mg/kg and 2 mM, respectively) blocked the anticonvulsant effects induced by intraperitoneal administration of 2-chloroadenosine.”

“Pretreatment with caffeine blocked the anticonvulsant effects of 2-CLA dose-dependently.”

“ Caffeine in a single dose of 23.1 mg/kg reduced the anticonvulsant effect of PB.”

“ Caffeine sodium benzoate in doses of 0.0595‐0.476 mmol/ kg (11.55–92.4 mg/kg) distinctly reduced the anticonvulsant efficacy of PB, in the highest dose tested with an increase in ED50 value from 19.5 to 38 mg/kg.”

“Further, when subconvulsant doses of caffeine and DMCM were combined, a synergistic action was observed.”