Possible Interaction: Anti-Inflammatory Agents, Non-Steroidal and Vitamin D

“Furthermore, some medications such as vitamin, mineral, fatty acid supplementations, oral contraceptive pills, colchicine, steroid hormones (orally or injected), antiepileptic agents, anticoagulants, anti-inflammatory drugs , antihypertensive treatment including angiotensin-converting enzyme inhibitors, angiotensin receptor blocker, statins, used may influence vitamin D level.”

“Also, some medications such as antihypertensive treatment including angiotensin-converting enzyme inhibitors, angiotensin receptor blocker, statins, anti-inflammatory drugs used may influence vitamin D level [6].”

“Furthermore, some medications such as antihypertensive treatment, including angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, statins and anti-inflammatory drugs may influence vitamin D levels.”

“Among nonusers of aspirin or other NSAIDs , the CC genotype conferred a significant decrease in risk of adenoma (OR, 0.26; 95% CI, 0.07-0.89).”

“To determine whether nonsteroidal anti-inflammatory agents also were capable of enhancing the differentiation of HL-60 leukemia cells produced by vitamin D3 , we measured the effects of a variety of nonsteroidal anti-inflammatory agents on the maturation of HL-60 cells produced by low levels of vitamin D3.”

“… nonsteroidal anti-inflammatory agents also enhanced … with vitamin D analogs which share the receptor binding properties of vitamin D3; however, a vitamin D analog which caused significant calcium mobilization, … vitamin D3, did not induce the differentiation of HL-60 cells in the presence or absence of anti-inflammatory agents.”

“This is the first study to provide evidence of interactions between vitamin D and the immune system in relation to breast cancer ER status, which may inform combinational use of vitamin D and anti-inflammatory drugs for cancer prevention and therapy.”