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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Vitamin B 6
Research Papers that Mention the Interaction
“ Vitamin B-6 status should be carefully monitored in long-term NSAID users.”
Clinical use of cyclooxygenase inhibitors impairs vitamin B-6 metabolism.“Abstract Kinetic studies have shown that a number of acidic anti-inflammatory drugs (salicylate, “Ibufenac”, phenylbutazone, Indomethacin and Flufenamic acid) inhibit histamine formation by competing with pyridoxal phosphate for the coenzyme binding site, believed to be a lysyl ϵ-amino group on mammalian histidine decarboxylase.”
Biochemical properties of anti-inflammatory drugs. 8. Inhibition of histamine formation catalyzed by substrate specific mammalian histidine decarboxylases. Drug antagonism of aldehyde binding to protein amino groups.
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