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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Anti-Inflammatory Agents, Non-Steroidal and Trehalose

Research Papers that Mention the Interaction

Our results suggest that co-lyophilization of NSAIDs with trehalose might be a novel procedure that can help prevent NSAIDs-induced skin irritation.
The anti-inflammatory effect of co-lyophilized NSAIDs with trehalose was comparable to that seen with NSAIDs alone in a rat model.
Using the three-dimensional cultured human skin model, Living Skin Equivalent-high, we found that cutaneous damage due to NSAIDs was reduced by concomitant use of trehalose and that this effect of trehalose was reinforced by co-lyophilization of NSAIDs with trehalose.
We hypothesized that the cutaneous irritation by topical NSAIDs might be suppressed by trehalose , which has protective effects on biological membranes.
The Journal of veterinary medical science  •  2013  |  View Paper