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Last Updated: 3 years ago
supplement:
Carrageenan
Research Papers that Mention the Interaction
“Results A sciatic block with bupivacaine as well as a systemic injection of NSAID significantly decreased the oedema and the thermal and mechanical hyperalgesia induced by carrageenan.”
Comparison of a bupivacaine peripheral nerve block and systemic ketoprofen on peripheral inflammation and hyperalgesia in rats“The exudate volume was also significantly decreased when indomethacin, a cyclooxygenase inhibitor, or dexamethasone, a steroidal antiinflammatory drug , was coinjected with carrageenan.”
“In rat hind paw model, subplantar carrageenan injection produced peak inflammatory swelling after about 4 hr which was significantly reduced by all anti-inflammatory drugs mentioned above.”
“ Non-steroidal anti-inflammatory drugs (NSAID) only partially inhibit the hyperalgesia in the inflammation induced by carrageenin in the hind rat paw, one of the most frequently used nociceptive tests.”
“ Non‐steroidal anti‐inflammatory agents were found to reduce cell accumulation in response to carrageenan , but were unable to prevent proteoglycan loss from cartilage.”
“In rat carrageenin pleurisy, both steroidal and non-steroidal anti-inflammatory drugs (SAID and NSAID respectively) produced a dose-related reduction of exudate volume and of prostaglandin (PG)E2 contents in the exudate at 3 h after carrageenin.”
“ NSAID reduced leucocyte number and total activities of lysosomal enzymes in the exudate at 3 h after carrageenin only at the higher doses, while SAID did so in a dose-related manner.”
“During the development of an acute inflammatory process, provoked by carrageenan injection, the treatment with non-steroidal anti-inflammatory agents induces an enhancement of hepatic TPO activity.”
“However, arachidonic acid potentiation of carrageenan oedema was reduced by pretreatment with non‐steroidal anti‐inflammatory drugs but not by anti‐inflammatory steroids or by paracetamol.”
“Since edema produced by the polysaccharide carrageenin is also highly susceptible to inhibition by anti-inflammatory drugs , this relationship may reflect a similarity in the mode of action of polysaccharides.”
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