Possible Interaction: Anti-Inflammatory Agents, Non-Steroidal and Calcium Supplement

“ConclusionsThis study confirms that NSAIDs reduce urine wasting of sodium and calcium in patients with BS.”

“Of them, a study found a higher intake of calcium decreases the risk of adenoma recurrence by approximately 45%.… in a population of patients with history of previous colonic neoplasia.13 Moreover, a lower-fat diet and regular nonsteroidal anti-inflammatory drug use … calcium ’s effectiveness as … tested agents.”

“We conclude that aspirin or NSAID use may shorten survival in ALS, while calcium use may prolong survival.”

“Conclusion: Data from two different randomized clinical trials suggest that calcium and NSAIDs may act synergistically to lower the risk of advanced colorectal neoplastic polyps.”

“At first, NSAIDs were thought to work by reducing inflammation but in 2001, Edward Koo (University of California San Diego, La Jolla, CA , USA), Todd Golde (Mayo Clinic, Jacksonville, FL, USA), and others reported that some NSAIDs reduced A 42 production in cultured cells and mouse brains.”

“Histamine and Ca added to NSAIDs amplified the activating effect of the latter on CA II.”

“ Non-steroidal anti-inflammatory drugs (NSAID) have been shown to decrease calcium excretion in the experimental animal, in human volunteers and in calcium stone formers.”

“Therefore, the regulation of the selective secretion of lysosomal enzymes from neutrophils by nonsteroid anti-inflammatory agents may be related to their capacity to modulate the association of calcium with these cells.”

“ NSAIDs therefore inhibit early steps in neutrophil activation as reflected by their capacity to inhibit movements of Ca and to enhance intracellular levels of cyclic AMP.”