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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Caffeine
Research Papers that Mention the Interaction
“In preclinical studies, caffeine produces intrinsic antinociceptive effects in several rodent models, and augments the actions of NSAIDs and acetaminophen.”
Methylxanthines and pain.“ Caffeine is an effective analgesic adjuvant because it increases the antinociceptive effect of NSAIDs while reducing the probability of side effects.”
“Combined administration of caffeine and ketorolac ( NSAID ) is accompanied by all possible types of drug interaction.”
“Thus, the amplification of ketorolac effects by caffeine must be taken into consideration in prescribing NSAIDs.”
[Studying toxicity caused by interaction of caffeine and ketorolac].“It has been observed that caffeine improves antinociceptive efficacy of some non-steroidal antiinflammatory drugs (NSAIDs) in several experimental models, however, these effects have been questioned in humans.”
“It has been suggested that caffeine can augment analgesic activity and aggravate side effects of nonsteroidal anti-inflammatory drugs (NSAIDs).”
“This suggests that caffeine potentiates the nephrotoxicity of the non-steroidal anti-inflammatory drug , mefenamic acid, on the rat renal papilla.”
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