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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Anti-Inflammatory Agents, Non-Steroidal and Caffeine

Research Papers that Mention the Interaction

In preclinical studies, caffeine produces intrinsic antinociceptive effects in several rodent models, and augments the actions of NSAIDs and acetaminophen.
Handbook of experimental pharmacology  •  2011  |  View Paper
Caffeine is an effective analgesic adjuvant because it increases the antinociceptive effect of NSAIDs while reducing the probability of side effects.
Journal of pharmacological and toxicological methods  •  1999  |  View Paper
Combined administration of caffeine and ketorolac ( NSAID ) is accompanied by all possible types of drug interaction.
Thus, the amplification of ketorolac effects by caffeine must be taken into consideration in prescribing NSAIDs.
Eksperimental'naia i klinicheskaia farmakologiia  •  2012  |  View Paper
It has been observed that caffeine improves antinociceptive efficacy of some non-steroidal antiinflammatory drugs (NSAIDs) in several experimental models, however, these effects have been questioned in humans.
European journal of pharmacology  •  2006  |  View Paper
It has been suggested that caffeine can augment analgesic activity and aggravate side effects of nonsteroidal anti-inflammatory drugs (NSAIDs).
Pharmacology  •  2001  |  View Paper
This suggests that caffeine potentiates the nephrotoxicity of the non-steroidal anti-inflammatory drug , mefenamic acid, on the rat renal papilla.
American journal of nephrology  •  1990  |  View Paper