Possible Interaction: Anti-Inflammatory Agents, Non-Steroidal and Arachidonic Acid

“The NSAIDs , including aspirin, are relatively specific inhibitors of one branch of the arachidonic acid cascade ; this inhibition occurs through cyclooxygenase inhibition, which may modulate carcinogenesis.”

“ NSAIDs act through inhibition of cyclooxygenase (COX) conversion of arachidonic acid into prostaglandins.”

“For instance, nonsteroidal anti‐inflammatory agents (NSAIDs), both classical nonselective (cNSAIDs) and the selective COX‐2 inhibitors (coxibs) attenuate the generation of PGH2 from AA that in turn reduces the synthesis of PGE2 and modifies the inflammatory conditions.”

“ Non‐steroidal anti‐inflammatory drugs exert their anti‐inflammatory and antipyretic effects by blocking the production of prostanoids from arachidonic acid through inhibition ofcyclooxygenase enzyme.”

“ Nonsteroidal antiinflammatory drugs (NSAIDs) modulating arachidonic acid (AA) metabolism have been utilized in cancer chemoprevention.”

“Since it was initially discovered that non-steroidal anti-inflammatory drugs inhibit prostaglandin synthesis, a vast amount of drug development has been performed to selectively inhibit the production of the inflammatory metabolites of arachidonic acid while preserving their protective role.”

“Administration of nonsteroid anti-inflammatory drugs AID ) inhibits hypotension and bronchoconstriction induced by the polyunsaturated prostaglandin (PG) precursor arachidonic acid (AA) and by slow reacting substance C (SRS-C, a mixture of unsaturated fatty acids split from lecithin by snake venom phospholipase A2).”

“Furthermore, formation of mediators in PRP by AA was accompanied by a calcium dependent and serum independent platelet aggregation, liable as well to blockade by AID.”

“SummaryAll acidic non-steroidal anti-inflammatory drugs suppress the activity of microsomal cyclo-oxygenase of arachidonic acid ; therefore, these drugs are equipotent inhibitors of prostaglandin and thromboxane generation.”

“ Non-steroidal anti-inflammatory drugs inhibit prostaglandin synthetase and the ocular effects of arachidonic acid , its substrate.”

“For example, … of the arachidonic acid cascade are considered to be mediators of the inflammatory response: they are formed during the process, contribute to the symptoms of …, vascular leakage, fever, pain and chemotaxis, and inhibition of their biosynthesis can be achieved at different levels by the anti-inflammatory drugs.”