Possible Interaction: Anti-Inflammatory Agents, Non-Steroidal and Antioxidants

“Studies have shown less cognitive decline and lower risk of Alzheimer's disease in elderly individuals consuming either antioxidant vitamins or nonsteroidal anti‐inflammatory drugs ( NSAIDs).”

“These results suggest that among elderly individuals with an APOE ε4 allele, there is an association between using antioxidant supplements in combination with NSAIDs and less cognitive decline over time.”

“Co-administration of antioxidants and anti-inflammatory drugs has shown clinical benefits.”

“… nonsteroidal anti-inflammatory drugs , opioid drugs) and many … between pro-oxidant and antioxidant processes in the mammalian tissues and these properties of drugs such as indomethacin, meloxicam, tenoxicam, valdecoxib or some metabolites …-related toxic effects, including gastrointestinal ulcers, hepatic failure, agranulocytosis, aplastic anemia, neutropenia, opiate-induced hyperalgesia and tolerance.”

“The reduced AD risk associated with high intake of both nonsteroidal anti‐inflammatory drugs (NSAIDs) and antioxidants suggests causal roles, but clinical trials in AD patients have yielded only limited or negative results.”

“Based on our hypothesis and … that a combination of nonsteroidal anti-inflammatory drugs, … antioxidant vitamins , which quench free radicals and both of which have been recently reported to be of some value …, may be much more effective in the prevention and treatment of AD than the individual agents alone.”

“juice (ABJ) contains antioxidant polyphenols that could reduce the need to use non-steroidal anti-inflammatory drugs , currently employed in cancer treatment, to prevent its side effects.”

“The prolonged NSAID therapy also decreased the antioxidant potential of the patients with rheumatoid arthritis as well as the individuals with no signs of rheumatoid arthritis. •”

“Anti-inflammatory compounds such as intravitreal glucocorticoids, topical non-steroidal anti-inflammatory drugs NSAIDs), antioxidants , inflammatory molecule inhibitors, renin-angiotensin system (RAS) blockers and natural anti-inflammatory therapies may all be considered to reduce the rate of administration of antineovascularization agents in the treatment of DR.”

“We speculate that addition of antioxidants as dietary supplements to NSAID treatment regimens would reduce the magnitude of decreased barrier function, specifically the transepithelial passage of bacteria.”

“Our results suggest that NSAIDs have different influences on oxidative stress and anti-oxidant system related parameters.”