“Nerves treated with highly lipid-soluble agents (bupivacaine, tetracaine, etidocaine), two experimental compounds … very low lipid solubility (GEA 968 and QX-572, respectively), and the antiarrhythmic agents took longer to develop and to recover from the … than those treated with drugs of moderate lipid solubility ( procaine , lidocaine, prilocaine, … benzocaine).”