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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Naringenin
Research Papers that Mention the Interaction
“Conclusions: There is an additive inhibitory effect on HERG current when naringenin is combined with IKr-blocking antiarrhythmic drugs.”
“ Naringenin blocked HERG current dose dependently with an IC50 of 173.3 ± 3.1 µM. Naringenin 100 µM alone inhibited HERG current by 31 ± 6%, and this inhibitory effect was increased with coadministration of 1 or 10 µM antiarrhythmic drugs.”
“When 100 µM naringenin was added to antiarrhythmic drugs , greater HERG inhibition was demonstrated, compared to the current inhibition caused by antiarrhythmic drugs alone.”
The Additive Effects of the Active Component of Grapefruit Juice (Naringenin) and Antiarrhythmic Drugs on HERG Inhibition
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