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“Reduction by RAN of INa,L-induced dysregulation of calcium cycling could contribute to the antiarrhythmic actions of this agent in both reentrant and triggered arrhythmias.”
“These findings are discussed in relation to the hypothesis that the antiarrhythmic action of certain drugs may reflect their ability to inhibit such lipid-facilitated transport of calcium from an aqueous to a lipid solvent phase.”
The Journal of pharmacology and experimental therapeutics • 1966 | View Paper
“The adjusted analysis revealed that use of antiarrhythmic and AV nodal blocking agents after initial CA may impact outcomes, and thus warrants prospective investigation.”