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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Anthraquinones
drug:
Nitric Oxide
Research Papers that Mention the Interaction
“The bianthraquinones significantly inhibited nitric oxide (NO) production and suppressed inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression in LPS-stimulated RAW 264.7 cells.”
Bioactive Bianthraquinones and Meroterpenoids from a Marine-Derived Stemphylium sp. Fungus“In vitro, HMA suppressed the production NO , TGF-β1, TNF-α, IL-6, and IL-1β in LPS-stimulated RAW 264.7 macrophage cells.”
Protective Effect of 2-Hydroxymethyl Anthraquinone from Hedyotis diffusa Willd in Lipopolysaccharide-Induced Acute Lung Injury Mediated by TLR4-NF-κB Pathway“ Phenanthraquinone inhibited NO formation evaluated by citrulline formed by total membrane fraction of bovine aortic endothelial cells with an IC(50) value of 0.6 microM. A kinetic study revealed that phenanthraquinone is a competitive inhibitor with respect to NADPH and a noncompetitive inhibitor with respect to L-arginine.”
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