Possible Interaction: Anthralin and Arachidonic Acid

“ Dithranol caused a reduction in the concentration of arachidonic acid at 10 days (167±42 and 358±55 ng ml-1 treated and control sites respectively, p<0.05) concurrent with clinical improvement of the lesions.”

“2 Topical arachidonic acid in concentrations which produced a small short-lived inflammatory response greatly augmented the initial phase and depressed the later phase of the inflammatory response to anthralin.”

“After treatment with dithranol , the arachidonic acid concentration increased to a maximum of 5556 ng ml-1 at 48 h whilst PGE2 increased to 93.4 ng ml-1 at 12 h and then declined.”

“A variety of different, experimentally induced human skin inflammatory stimuli including UV‐A (Barr et al., 1982a; Gilchrest et al., 1982), UV‐…, Hensby & Greaves, 1982), UV‐C (Camp et al., 1978), infra‐red (Hensby et al., 1982), trafuril (Plummer et al., 1977) and anthralin (Barr et … of arachidonic acid ….”

“These results indicate that anthralin synergistically stimulates TPA-caused PGE2 release by synergistically increasing arachidonic acid release and cellular cyclooxygenase activity.”

“A variety of chemical stimuli, including tetrahydrofurfuryl nicotinate (Plummer et al., 1977) and anthralin (Barr ei al., 1982) are known to increase the levels of arachidonic acid and various prostanoids recovered from the fiuid of suction blisters raised on hviman and animal skin.”