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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Anthocyanins
drug:
Sirolimus
Research Papers that Mention the Interaction
“Our results indicated that anthocyanins significantly decreased phospho-mTOR comparable to rapamycin , a synthetic mTOR inhibitor, and this inhibitory effect of anthocyanins on mTOR was completely abrogated by inactivating AMPKα1.”
Anthocyanins are novel AMPKα1 stimulators that suppress tumor growth by inhibiting mTOR phosphorylation.“The autophagy agonist rapamycin enhanced the anti-inflammatory effect of anthocyanin , while the autophagy inhibitor 3-methyladenine (3-MA) forbade its protective effect.”
“In addition, activation of protein kinase B (Akt), mammalian target of rapamycin (mTOR), and ribosomal protein S6 (S6) were significantly suppressed by anthocyanin exposure.”
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