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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Anthocyanins
drug:
Nitric Oxide
Research Papers that Mention the Interaction
“These results corresponded with NO levels, suggesting that BCE and anthocyanin may regulate NO synthesis via eNOS expression.”
Phytoestrogenic Effects of Blackcurrant Anthocyanins Increased Endothelial Nitric Oxide Synthase (eNOS) Expression in Human Endothelial Cells and Ovariectomized Rats“We found that anthocyanins contributed to suppression of ROS and p53, in association with increased NO production and eNOS dimerization.”
“Evidence suggests that anthocyanins modulate endothelial function, potentially by increasing nitric oxide ( NO ) synthesis, or enhancing NO bioavailability.”
“Distinct anthocyanins display opposing neuroprotective effects against nitric oxide.”
Chemical basis for the disparate neuroprotective effects of the anthocyanins, callistephin and kuromanin, against nitrosative stress“On the other hand, the ternatin anthocyanins (F4) inhibited nuclear NF-κB translocation, iNOS protein expression, and NO production through a non-ROS suppression mechanism.”
“Our results showed that anthocyanins significantly inhibited LPS-induced pro-inflammatory mediators, such as nitric oxide (NO) and prostaglandin E2, and pro-inflammatory cytokines including tumor necrosis factor (TNF)-α and interleukin (IL)-1β, without significant cytotoxicity.”
“ Anthocyanins had strong inhibitory effects on NO production.”
“This is the first study to report the inhibitory effects of anthocyanins and berry phenolic compounds on NO production.”
“After cloning of the nitric reductase (NR) gene from Lycium barbarum (LbNR) plants, we demonstrated that LbNR-derived NO partially inhibited anthocyanin biosynthesis but enhanced proanthocyanidin (PA) accumulation, and delayed fruit coloration.”
“Given there is a significant negative relationship between the levels of anthocyanins and PAs during Lycium fruit ripening, NO not only inhibited anthocyanin de novo biosynthesis but redirected the flavonoid biosynthetic pathway from anthocyanins to PA production.”
LbNR-Derived Nitric Oxide Delays Lycium Fruit Coloration by Transcriptionally Modifying Flavonoid Biosynthetic Pathway“A combined metabolomic and transcriptomic characterization of NO-deficient nia1,2noa1–2 mutant plants suggests that NO acts attenuating the production and accumulation of osmoprotective and regulatory metabolites, such as sugars and polyamines, stress-related hormones, such as ABA and jasmonates, and antioxidants, such as anthocyanins and flavonoids.”
“RESULTS Black soybean anthocyanins significantly decreased LPS-stimulated production of ROS, inflammatory mediators such as nitric oxide ( NO ) and prostaglandin E2, and pro-inflammatory cytokines, including tumor necrosis factor α and interleukin-6, in a dose-dependent manner without cytotoxicity (P < 0.001).”
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