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“The findings indicated that not only do some antioxidants improve antischistosomal activity of the two anthelmintics , but they exhibit activity per se, leading to high mortality of NTS post-exposure.”
“Administration of anthelmintic (praziquantel) and antioxidant (N-acetylcysteine plus deferoxamine) treatments was effective in inhibiting most of these phenotypes, and the combination of both treatments had a synergistic effect to prevent such changes.”
The Journal of biological chemistry • 2021 | View Paper
“In addition, a combination of anthelminthic drugs with antioxidant might be advantageous for modulating oxidative processes associated with schistosomiasis.”
“Therefore, attempting new combinations of anthelmintic drugs with other biomolecules such as antioxidants provides new avenues for discovery of alternatives to PZQ.”