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Possible Interaction: Anserine and Doxorubicin Hydrochloride

Research Papers that Mention the Interaction

Anserine increased the DOX induced antitumor activity by the maintained DOX concentration in the tumor in vivo.
Anserine was considered to take into tumor cells via a dipeptide transporter, and it resulted in an increase of the DOX influx.
Furthermore, anserine significantly induced DOX influx compared to that of the DOX alone group in vitro.
It is speculated that the anserine induced increase in the antitumor activity of DOX in vivo was affected by the promotion of DOX influx into the tumor cells in vitro.
Thus, anserine appeared to increase the antitumor activity of DOX with an increased DOX concentration in the tumor by specific action on the tumor.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association  •  2007  |  View Paper