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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Anethole Trithione
supplement:
Glutathione
Research Papers that Mention the Interaction
“A significant increase in cellular GSH was observed in cells that were treated with ADT for 72 hr.”
Protective effects of anethole dithiolethione against oxidative stress-induced cytotoxicity in human Jurkat T cells.“These findings indicate that ADT shifts the redox ratio of GSH and other thiols with their oxidized forms toward the reduced forms, thus favoring the dissociation of albumin-bound Hcys and its transfer to renal and hepatic cells for further processing.”
Anethole dithiolethione lowers the homocysteine and raises the glutathione levels in solid tissues and plasma of rats: a novel non-vitamin homocysteine-lowering agent.“Although no effect on the protein loss occurred, the presence of ADT during starvation counteracted the starvation-induced loss of intracellular glutathione in a concentration-dependent way.”
“… dithiolthiones to mice in single intragastric doses (2-4 mmol/kg body weight) or in the diet (0.… days), and to rats in the diet (0.1% for 14 days) was found to increase glutathione levels and the activities of a number … various tissues including the liver and lung.”
“ResultsOur structure–activity relationships data show that dithiolethione electronic properties, given as Hammett σp constants, influence glutathione induction activity and compound toxicity.”
Further structure–activity relationships study of substituted dithiolethiones as glutathione-inducing neuroprotective agents
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