Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 4 months ago

Possible Interaction: Anethole Trithione and Glutathione

Research Papers that Mention the Interaction

In this study, we showed that incubation of SH-SY5Y neuroblastoma … primary human neurons with micromolar concentrations (10-100 microM) of D3T for 24 h resulted in significant … the levels of reduced glutathione ( GSH ) and NAD(P)H:quinone oxidoreductase 1 (NQO1), … cellular defenses against oxidative and electrophilic stress.
Taken together, this study demonstrates that D3T potently induces neuronal cellular GSH and NQO1 as well as mitochondrial GSH, and that such upregulated endogenous defenses are accompanied by increased resistance to oxidative and electrophilic neurocytotoxicity.
Brain Research  •  2008  |  View Paper
In addition, D3T caused significant increases in mitochondrial GSH content and GR activity.
Molecular and Cellular Biochemistry  •  2006  |  View Paper
A significant increase in cellular GSH was observed in cells that were treated with ADT for 72 hr.
Biochemical pharmacology  •  1998  |  View Paper
These findings indicate that ADT shifts the redox ratio of GSH and other thiols with their oxidized forms toward the reduced forms, thus favoring the dissociation of albumin-bound Hcys and its transfer to renal and hepatic cells for further processing.
Biochemical pharmacology  •  2014  |  View Paper
Incubation of H9c2 cells with D3T resulted in a marked concentration- and time-dependent induction of a number of cellular antioxidants and phase 2 enzymes, including catalase, reduced glutathione ( GSH ), GSH peroxidase, glutathione reductase (GR), GSH S-transferase (GST), and NAD(P)H:quinone oxidoreductase-1 (NQO1).
Experimental biology and medicine  •  2006  |  View Paper
Both GSH and GST remained elevated for at least 72 h after removal of D3T from the culture media.
Treatment of cardiomyocytes with D3T resulted in a significant induction of both GSH and GST as well as the mRNA expression of gamma-glutamylcysteine ligase catalytic subunit and GSTA.
Archives of biochemistry and biophysics  •  2005  |  View Paper
Taken together, our results demonstrate that upregulating GSH biosynthesis by D3T results in a marked protection against ONOO−-induced toxicity in vascular cells.
Cardiovascular Toxicology  •  2004  |  View Paper
Notably, the levels of GSH and GST remained higher than basal levels 72 h after removal of D3T from the culture media.
Atherosclerosis  •  2003  |  View Paper
Incubation of A10 cells with D3T resulted in a marked concentration-dependent induction of both GSH and GST.
Cardiovascular Toxicology  •  2003  |  View Paper
Although no effect on the protein loss occurred, the presence of ADT during starvation counteracted the starvation-induced loss of intracellular glutathione in a concentration-dependent way.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  1998  |  View Paper
Show More