supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Anesthetics, Local
supplement:
Sodium Bicarbonate
Research Papers that Mention the Interaction
“The pH-adjustment of local anesthetic solutions with sodium bicarbonate may shorten onset time and improve spread of neural blockade.”
Peribulbar anesthesia. Effect of bicarbonate on mixtures of lidocaine, bupivacaine, and hyaluronidase with or without epinephrine.“ResultsClinical and statistical data confirmed that the addition of sodium bicarbonate in local anesthetics reduces pain and decreased the onset and increased duration of local anesthesia in the palatal site, as compared to injection of local anesthetic without sodium bicarbonate.”
“ConclusionIt has been observed in this study that the action of sodium bicarbonate in local anesthetics increases the pH levels of these solutions, thus possibly making them more effective in an acidic environment.”
“ResultsClinical and statistical data confirmed that the addition of sodium bicarbonate in local anesthetics did increase the efficacy of local anesthesia in inflamed tissues.”
“BACKGROUND Many physicians believe that buffering local anesthetics with sodium bicarbonate is the best technique for reducing the pain and discomfort associated with subcutaneous infiltration.”
“The addition of sodium bicarbonate as a buffering agent to the local anesthetics lidocaine and bupivacaine can significantly reduce pain upon injection.”
“Increasing the pH of local anesthetics with sodium bicarbonate has been reported to hasten their onset of action.”
“Background The potentiating effect of sodium bicarbonate on local anesthetic action is attributed to two mechanisms: (1) an increase in the un‐ionized local anesthetic due to extracellular alkalinization, and (2) an accelerated conversion of local anesthetic from un‐ionized to ionized form with intracellular acidification caused by bicarbonate.”
The Effects of Extracellular pH with and without Bicarbonate on Intracellular Procaine Concentrations and Anesthetic Effects in Crayfish Giant Axons“Background and objectives The use of sodium bicarbonate for alkalinization of local anesthetics to improve their efficacy has some disadvantages including decreased stability of the solutions.”
Alkalinizing Water-Soluble Local Anesthetic Solutions by Addition of Cyclodextrin“ Sodium bicarbonate has been added to various local anesthetics for shortening the onset time.”
“&NA; Several studies have indicated that the addition of sodium bicarbonate to solutions of local anesthetics to raise the pH closer to the pKa shortens the latency, increases the intensity, and prolongs the duration of the resultant neural blockade.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback