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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Anesthetics, Local
supplement:
Potassium
Research Papers that Mention the Interaction
“Based on lipophilic and hydrophilic properties, local anesthetics can interfere with ion channels such as sodium, potassium and calcium channels of the CNS and the heart leading to severe neuronal and cardiac (arrhythmia and contractile depression) adverse effects.”
[Complications of regional anesthesia: diagnostic and management].“These local anesthetics caused, especially in the higher concentrations, hemolysis and increased the passive loss of potassium from the cell and leak of sodium into the cell.”
“Like other local anesthetics , they suppressed both sodium and potassium conductance increases.”
Ionic mechanism of action of a spin-labeled local anesthetic on squid axon membranes“First, a toxic dose of local anesthetics can inhibit sodium, potassium , and calcium channels in cardiomyocytes, leading to conduction block, QRS widening, ventricular arrhythmia, and cardiac arrest.”
Putative Mechanisms Associated With Lipid Emulsion Treatment for Cardiac Toxicity Caused by Yew Intoxication.
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