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Last Updated: 2 years ago

Possible Interaction: Anesthetics, Local and Potassium

Research Papers that Mention the Interaction

Based on lipophilic and hydrophilic properties, local anesthetics can interfere with ion channels such as sodium, potassium and calcium channels of the CNS and the heart leading to severe neuronal and cardiac (arrhythmia and contractile depression) adverse effects.
Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS  •  2007  |  View Paper
These local anesthetics caused, especially in the higher concentrations, hemolysis and increased the passive loss of potassium from the cell and leak of sodium into the cell.
The Journal of pharmacology and experimental therapeutics  •  1965  |  View Paper
Like other local anesthetics , they suppressed both sodium and potassium conductance increases.
The Journal of Membrane Biology  •  2005  |  View Paper
First, a toxic dose of local anesthetics can inhibit sodium, potassium , and calcium channels in cardiomyocytes, leading to conduction block, QRS widening, ventricular arrhythmia, and cardiac arrest.
Pediatric emergency care  •  2020  |  View Paper