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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Anesthetics, Local
supplement:
Phosphatidylethanolamine
Research Papers that Mention the Interaction
“Evaluation of the accessibility of phosphatidylethanolamine towards cleavage by phospholipase A2 in the presence of local anesthetics indicates accessible fractions much higher than those obtained after removal of the perturbant.”
Bacterial cytotoxins, amphotericin B and local anesthetics enhance transbilayer mobility of phospholipids in erythrocyte membranes. Consequences for phospholipid asymmetry.“At concentrations of 1–10 mM, propranolol and local anesthetics inhibited labeling of phosphatidylcholine and phosphatidylethanolamine by more than 90% and incorporation of 32Pi into other phospholipids to a smaller extent.”
“d) LA produce a marked fall in the pH of cephalin sols equivalent to that produced by calcium, (e) Ca2+ and LA form 1:2 molar complexes with phospholipids probably by ion-ion and ion-induced polar type of binding at the phosphate groups of the lipid.”
Reaction of Local Anesthetics with Phospholipids
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