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Last Updated: 2 years ago

Possible Interaction: Anesthetics, Local and Epinephrine

Research Papers that Mention the Interaction

It is widely accepted that local anesthetics with epinephrine should not be used in areas served by terminal vessels.
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG  •  2014  |  View Paper
In young children, epidural anesthesia induces an increase in cardiac output only when adrenaline is added to local anesthetics , probably through its systemic absorption from the epidural space.
Anesthesia and analgesia  •  2004  |  View Paper
Background and Objectives: Epinephrine is used with local anesthetics to prolong the duration of epidural analgesia and decrease the peak plasma concentrations of local anesthetics.
Regional anesthesia and pain medicine  •  2000  |  View Paper
BACKGROUND Local anesthetic nerve block prolonged by epinephrine is thought to result from local vasoconstriction and consequent decreased local anesthetic clearance from the injection site.
Anesthesiology  •  1999  |  View Paper
Firstly, the presence of 0.15 mg of adrenaline in the local anaesthetic solution used conferred little, if any, prophylaxis against bronchospasm.
Anaesthesia  •  1993  |  View Paper
Two‐way analysis of variance showed that the addition of adrenaline to the local anaesthetic solution , but not the choice of using arterial or venous serum for analysis, significantly correlated to the lowering of the S‐K concentration (P <0.001).
Acta anaesthesiologica Scandinavica  •  1991  |  View Paper
Epinephrine added to the local anesthetic solution significantly increased the duration of action of both drugs.
Anesthesia and analgesia  •  1980  |  View Paper
In addition, various agents such as antibiotics, preservatives, opioids, epinephrine , and propofol can combine with LAs and affect their antimicrobial properties through synergistic or antagonistic action.
European Journal of Clinical Microbiology & Infectious Diseases  •  2018  |  View Paper
It can be concluded that potentially significant amounts of epinephrine can be absorbed systemically from the local anesthetic solution , that secretion of endogenous epinephrine in response to stress occurs, often at levels sufficient to cause measurable changes in hemodynamic variables, and that absorption of epinephrine from impregnated strings occurs.
The Journal of prosthetic dentistry  •  1985  |  View Paper
According to the pharmaceutical guidelines, the use of epinephrine as an additive to local anesthetics is contraindicated for these areas.
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG  •  2021  |  View Paper
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