Possible Interaction: Anesthetics, Local and Capsaicin

“This may originate by the lack of strong, conclusive evidences of its effectiveness, by the variety of therapeutic schemes used in literature, and finally by the unpleasant effects of the exposure to capsaicin , which are only partly relieved by the pretreatment with local anesthetics.”

“ Capsaicin , acting at the vanilloid 1 receptor (VR1), may potentiate local anesthetic activity , and as a ligand-gated ion channel of the transient receptor potential family, may also be a target for IV general anesthetics.”

“After the injection of capsaicin , both tertiary amine local anesthetics and their quaternary ammonium derivatives can elicit a prolonged and predominantly sensory/nociceptor selective block.”

“Conclusions:Combined administration of local anesthetics with the transient receptor potential vanilloid 1 agonist capsaicin induced a near complete blockade of incision-induced hypersensitivity for several days.”

“Further, we have shown recently that these nonselective cation channels, when activated by capsaicin , are potently and reversibly blocked by external application of quaternary ammonium compounds and local anesthetics.”

“Recent reports have demonstrated that the coadministration of capsaicin with a local anesthetic ( LA) at the rat sciatic nerve elicits a prolonged nociceptive-selective nerve block, suggesting that activation of the TRPV1 receptor may allow LAs to enter the nerve through the TRPV1 pore.”

“Conclusions: Both tertiary amine local anesthetics and their quaternary ammonium derivatives can elicit a predominantly sensory/nociceptor selective block when followed by injection of capsaicin.”