supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 5 years ago
drug:
Anesthetics, Local
supplement:
Caffeine
Research Papers that Mention the Interaction
“The uncoupling effect of caffeine is completely blocked by ruthenium red and by the local anesthetics , tetracaine, procaine, and benzocaine.”
[Blockers of the uncoupling action of caffeine on the Ca2+-transport function of sarcoplasmic reticulum membranes].“… caffeine in a dose-dependent manner 1) … tail in the presence of agents ( local anesthetics , tetrodotoxin, high potassium) that have been shown to diminish the force of contraction, presumably by decreasing cellular … presence of veratridine, and 8) fails to induce a marked tail in the presence of metabolic inhibitors.”
“Evidence is presented that the inhibitory effect of the local anesthetics cannot be explained by the formation of molecular complexes with caffeine.”
“ Local anesthetics have been found to act as competitive inhibitors of caffeine in frog sartorius muscle.”
Inhibition of Caffeine Rigor and Radiocalcium Movements by Local Anesthetics in Frog Sartorius Muscle
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback