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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Anesthetics, Local
supplement:
Caffeine
Research Papers that Mention the Interaction
“The uncoupling effect of caffeine is completely blocked by ruthenium red and by the local anesthetics , tetracaine, procaine, and benzocaine.”
[Blockers of the uncoupling action of caffeine on the Ca2+-transport function of sarcoplasmic reticulum membranes].“… caffeine in a dose-dependent manner 1) … tail in the presence of agents ( local anesthetics , tetrodotoxin, high potassium) that have been shown to diminish the force of contraction, presumably by decreasing cellular … presence of veratridine, and 8) fails to induce a marked tail in the presence of metabolic inhibitors.”
“Evidence is presented that the inhibitory effect of the local anesthetics cannot be explained by the formation of molecular complexes with caffeine.”
“ Local anesthetics have been found to act as competitive inhibitors of caffeine in frog sartorius muscle.”
Inhibition of Caffeine Rigor and Radiocalcium Movements by Local Anesthetics in Frog Sartorius Muscle
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