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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Androstenedione
drug:
Valproic Acid
Research Papers that Mention the Interaction
“The mean serum level of androstenedione was high in patients taking VPA.”
Reproductive effects of valproate, carbamazepine, and oxcarbazepine in men with epilepsy“At all concentrations of VPA , follicular development was suppressed, and androstenedione , testosterone, estradiol, and combined levels of all steroid hormones tended to decrease in association with suppression of aromatase expression in granulosa cells.”
Evaluation of ovarian toxicity of sodium valproate (VPA) using cultured rat ovarian follicles.“ VPA reduced (P<0.0001) both basal (70% suppression; IC50 67±10 µg/ml) and LH-induced (93% suppression; IC50 58±10 µg/ml) androstenedione secretion by TC.”
“Treatment of T-I cells with 8-Bromo-cAMP resulted in a marked increase in the production of androstenedione , and VPA inhibited this stimulatory effect, suggesting that the mechanism of VPA’s inhibitory effect on androstenedione production occurs at a step after second messenger activation.”
“RESULTS: Mean total serum testosterone and androstenedione levels were higher (P < 0.02) in the VPA group compared with the LTG group.”
What Valproate Does and Doesn't Do
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