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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Androstenedione
drug:
Trilostane
Research Papers that Mention the Interaction
“Results of in vitro studies using the human adrenal H295R cells treated with the HSD3B2 inhibitor, trilostane , also demonstrated a markedly decreased androstenedione production.”
Human adrenal cells that express both 3β-hydroxysteroid dehydrogenase type 2 (HSD3B2) and cytochrome b5 (CYB5A) contribute to adrenal androstenedione production“ Trilostane suppressed the intracellular production of androstenedione , testosterone, and dihydrotestosterone from dehydroepiandrosterone in LNCaP-FGC cells.”
“Finally, endocrine studies on postmenopausal women with advanced breast cancer show that Trilostane significantly reduces the plasma levels of estrone and of its major androgen precursor ( androstenedione).”
“ Trilostane afforded reduction of plasma levels of aldosterone, progesterone, deoxycorticosterone, 17-OH progesterone, cortisol, delta 4-androstenedione , and urinary excretion of 17-hydroxycorticosteroid.”
“ Trilostane is thought to be a competitive inhibitor of the 3beta-hydroxysteroid dehydrogenase (3beta-HSD), an essential enzyme system for the synthesis of cortisol, aldosterone and androstenedione.”
Cortisol, aldosterone, cortisol precursor, androgen and endogenous ACTH concentrations in dogs with pituitary-dependant hyperadrenocorticism treated with trilostane.
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