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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Androstenedione
drug:
Spironolactone
Research Papers that Mention the Interaction
“Mean serum levels of testosterone, androstenedione and dehydroepiandrosterone-sulfate decreased significantly with spironolactone but showed no change with cimetidine.”
Spironolactone and cimetidine in treatment of acne.“Biologically, testosterone and delta-4 androstenedione levels were significantly decreased with cyproterone acetate and spironolactone compared to no treatment.”
“Clearly, the cross-reactivity of spironolactone with the androstenedione assay in this patient was higher than that quoted by the manufacturer.”
“It was concluded that spironolactone had interfered with the measurement of androstenedione using the Direct Androstenedione Coat-A-Count (CAC) radioimmunoassay (Siemens Healthcare).”
“The manufacturer suggests that the cross-reaction of spironolactone with androstenedione in this assay is 0 109%; this implies that our patient’s blood spironolactone concentration would have to have been greater than 4000 ng/ml to give this androstenedione result through interference.”
“We present a case in which spironolactone interfered with androstenedione measurement, the result of which changed risk stratification for malignancy.”
“Results Spironolactone treatment was associated with higher androstenedione concentrations measured by the CAC assay that reverted to normal on treatment withdrawal.”
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