Possible Interaction: Androstenedione and Rifampin

“There was no significant difference in the formation of 17-hydroxyprogesterone between rifampicin-treated animals and the controls; however, a significant increase was found in the androstenedione fraction (+83%) and the testosterone fraction (+48%) under the influence of rifampicin.”

“These findings suggest that rifampicin stimulates the activity of 17 alpha-hydroxylase in the microsomal fraction of rat testes, thus leading to an increased formation of testosterone and androstenedione ; in contrast, the 17, 20-lyase and 17 beta-hydroxysteroid-dehydrogenase remain unaffected by rifampicin.”