Possible Interaction: Androstenedione and Recombinant Human Chorionic Gonadotropin

“Circadian changes in androstenedione levels were evident after hCG administration.”

“Incubation of 4-NP treated cells with hCG significantly (P < 0.001) inhibited androstenedione , but not testosterone, formation at the highest concentration (5.0 μg/mL).”

“ Androstenedione after stimulation with HCG , increased to a detectable level in both TV-blood and the testis.”

“IT ADD and IT DHEA were suppressed by 98 and 82%, respectively, by acyline and significantly increased with hCG administration.”

“In contrast, in group 1, the basal concentrations of serum 17-hydroxyprogesterone (17-OHP), androstenedione , testosterone and estradiol (E(2)) were stimulated significantly (17-OHP 105%, androstenedione 31%, testosterone 20%, E(2) 136%) by HCG , and the treatment with GnRH agonist decreased the responses.”

“Upon hCG stimulation , plasma testosterone increased 2.1-fold while androstenedione increased 1.4-fold.”

“ hCG induced significant increases in serum pregnenolone, 17-hydroxyprogesterone, androstenedione , testosterone, and dihydrotestosterone.”

“Serum 17-OH progesterone, androstenedione , and testosterone levels were extremely low before and after gonadal stimulation with hCG.”

“When follicles cultured with androstenedione were treated with hCG and EGF, the first polar body exclusion, chromosome alignment on metaphase plate, and spindle assembly were inhibited in the oocytes.”

“Administration of hCG resulted in an increase of plasma cortisol and androstenedione concentrations.”