Possible Interaction: Androstenedione and Progesterone

“However, androstenedione and progesterone decreased significantly over time in both groups.”

“Physiological concentrations of progesterone inhibited andostenedione production by dispersed thecal cells from the substrate 17 alpha-hydroxyprogesterone but not dehydroepiandrosterone in both a dose- and time-dependent manner.”

“Diethylstilbestrol, ethinylestradiol, mestranol, progesterone , and pregnenolone all inhibited the placental conversion of androstenedione to estrogens, but these compounds did not produce observable Type I difference spectra.”

“Abstract Addition of progesterone to the incubation medium increased the in vitro conversion of testosterone to androstenedione in rat prostatic tissue (as previously shown by Patwardhan and Lanthier, J. Steroid Biochem.”

“RESULTS Testosterone and an rostenedione co ncentrations were significantly higher during the menstrual cycle mid and lut eal ph ases than the early follicular phase, with median (range) values across the cycle of 0.34 nmol/L (0.04-1.01) and 1.97 nmol/L (0.53-7.89) respectively.”

“FF estrogen, androstenedione and anti-Müllerian hormone decreased significantly while progesterone increased, accompanied by radical changes in the expression of steroidogenic genes (CYP17A, CYP19A, HSD11B1 and HSD11B2, StAR).”

“ Androstenedione increased progesterone production 3-fold at a concentration of 1 mumol and more than 20-fold at 18 mumol.”

“Under these conditions, dehydroepiandrosterone and androstenedione inhibited progesterone output by explants of chorion obtained at spontaneous labor and at cesarean section.”

“The enzyme activity for progesterone was inhibited by estrone and androstenedione but not by estriol.”

“Moreover, we have established that androstenedione , the main circulating androgen in pregnant rats, significantly reduces the decline in luteal weight observed during postpartum structural regression.”