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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Androstenedione
drug:
Phenobarbital
Research Papers that Mention the Interaction
“Treatment of the animals with repeated doses of phenobarbitalin vivo caused an enhanced rate of formation of 5α-androstane-3,17-dione and of polar metabolites from this steroid.”
Influence of phenobarbital pretreatment on thein vitro ring a reduction of Δ4-3-oxo-steroids in rat liver microsomes“ Phenobarbital administration to rabbits resulted in 49-fold and 23-fold increases in the transformation of androst-4-ene-3,17-dione and dehydroepiandrosterone, respectively, into estriol by lymphocytes.”
“For instance, the administration of phenobarbital or chlorcyclizine to rats increases several fold the ability of liver microsomes to hydroxylate testosterone and Δ4-androstene-3,17-dione.”
INDUCED SYNTHESIS OF OXIDATIVE ENZYMES IN LIVER MICROSOMES BY POLYCYCLIC HYDROCARBONS AND DRUGS.
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