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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Androstenedione
drug:
Nicotine
Research Papers that Mention the Interaction
“In choriocarcinoma cell cultures, nicotine , cotinine (a major metabolite of nicotine), and anabasine (a minor component of cigarette tobacco) all inhibited androstenedione conversion to estrogen in a dose-dependent fashion.”
“In the choriocarcinoma cell cultures, a supraphysiologic concentration of androstenedione (73 microM) in the culture medium blocked the inhibition of aromatase caused by nicotine , cotinine, and anabasine.”
Nicotine, cotinine, and anabasine inhibit aromatase in human trophoblast in vitro.“Treatment of theca interna with 6, 60, and 600 micro M nicotine decreased (P<or=0.002) production of androstenedione to 55, 53, and 24% of control levels, respectively.”
Effects of nicotine and cotinine on bovine theca interna and granulosa cells.“ Nicotine produced a dose dependent increase in progesterone levels and a dose-dependent decrease in androstenedione and testosterone concentrations.”
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