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Last Updated: 2 years ago

Possible Interaction: Androstenedione and Nicotine

supplement:

Androstenedione

Research Papers that Mention the Interaction

In choriocarcinoma cell cultures, nicotine , cotinine (a major metabolite of nicotine), and anabasine (a minor component of cigarette tobacco) all inhibited androstenedione conversion to estrogen in a dose-dependent fashion.
In the choriocarcinoma cell cultures, a supraphysiologic concentration of androstenedione (73 microM) in the culture medium blocked the inhibition of aromatase caused by nicotine , cotinine, and anabasine.
The Journal of clinical investigation  •  1986  |  View Paper
Treatment of theca interna with 6, 60, and 600 micro M nicotine decreased (P<or=0.002) production of androstenedione to 55, 53, and 24% of control levels, respectively.
Reproductive toxicology  •  2002  |  View Paper
Nicotine produced a dose dependent increase in progesterone levels and a dose-dependent decrease in androstenedione and testosterone concentrations.
Journal of steroid biochemistry  •  1989  |  View Paper