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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Androstenedione
drug:
Metyrapone
Research Papers that Mention the Interaction
“… delta 4-androstenedione (delta … metyrapone (450 mg/m2 X dose, every h for 7 doses) in ACTH-intact hypopituitary children with multiple or isolated pituitary hormone deficiencies […, 27-566); delta 4-A, 313 ng/dL (range, 105-651)], except in 2 young children in whom DHEA did not rise.”
Adrenal androgen response to metyrapone, adrenocorticotropin, and corticotropin-releasing hormone stimulation in children with hypopituitarism.“While substantial findings have implicated cytochrome P-450 in placental aromatization, the aromatizaiton of androstenedione is insensitive to CO although it is competitively inhibited by metyrapone.”
“ Metyrapone evoked a pronounced rise in androstenedione and a slight rise in testosterone in 2 obese but healthy women.”
“ Metyrapone treatment significantly reduced basal, but not LH-stimulated output of androstenedione by whole small yellow follicles compared to that observed in control hens.”
Effect of metyrapone on the timing of oviposition and ovarian steroidogenesis in the laying hen.“Significant elevations in both testosterone (0.28 ng/min in control, 1.72 ng/min in Metopirone treated) and androstenedione (6.72 ng/min in control, 33.44 ng/min in Metopirone treated) were observed after treatment with Metopirone (p < 0.01).”
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