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Last Updated: 2 years ago

Possible Interaction: Androstenedione and Leptin

supplement:

Androstenedione

drug:

Leptin

Research Papers that Mention the Interaction

On the contrary, dihydrotestosterone, androstenedione and dehydroepiandrosterone-S are potent inhibitors of leptin secretion, while estradiol induces a strong stimulation in adipose tissue taken from women.
Pituitary  •  2004  |  View Paper
In OW patients the significant positive correlation between leptin levels and androstenendione was found (P < 0.001), after correction for BMI.
International journal of fertility and women's medicine  •  2007  |  View Paper
In eumenorrheic volunteers, leptin and androstenedione concentrations also covaried in a lag-specific manner (0.0001 < P < 0.01), but this linkage was disrupted in patients with polycystic ovarian syndrome.
The Journal of clinical endocrinology and metabolism  •  2001  |  View Paper
Exposure to androstenedione also resulted in a significant reduction (P<0.01) of leptin secretion in samples taken from women (2231+/-264), with no effect on male adipose tissue (1605+/-544).
In conclusion, DHT, stanozolol, DHEA-S and androstenedione induced a significant inhibition of in vitro leptin secretion in samples from female donors, without affecting the secretion in samples from men.
The Journal of endocrinology  •  1999  |  View Paper
The inhibitory effect of leptin on hCG-induced T secretion was accompanied by a significant reduction of androstenedione and a concomitant rise of the precursor metabolites pregnenolone, progesterone, and 17-OH-progesterone, conceivable with a leptin-induced lesion of 17,20 lyase activity.
Endocrinology  •  1999  |  View Paper
In contrast, leptin blocked (p < 0.05) insulin-induced progesterone and androstenedione production by thecal cells.
Biology of reproduction  •  1998  |  View Paper
The inhibitory effect of leptin on hCG-induced T secretion was accompanied by a significant reduction of androstenedione and a concomitant rise of the precursor metabolites pregnenolone, progesterone, and 17-OHprogesterone, conceivable with a leptin-induced lesion of 17,20 lyase activity.
Endocrinology  •  1999  |  View Paper